Effect of Supplementation with n-3 Fatty Acids Extracted from Microalgae on Inflammation Biomarkers from Two Different Strains of Mice

Table 5

Effect of supplementation with EPA and DHA fatty acids extracted from microalgae on Th1 and Th2 cytokines in CD1.

CD1 mice	8 weeks old	16 weeks old
	BL	RC	MD	LY	SAT
	Mean ± SD	Mean ± SD	Mean ± SD	Mean ± SD	Mean ± SD
Th1; % TCD4+/
IFN-γ	1.8 ± 0.18	1.2 ± 0.09	2.7 ± 0.1	1.0 ± 0.1	4.3 ± 0.1
TNF-α	2.5 ± 0.13	1.5 ± 0.1	2.6 ± 0.1	1.4 ± 0.09	4.6 ± 0.07
IL-12	2.8 ± 0.1	1.7 ± 0.08	2.4 ± 0.09	1.3 ± 0.08	4.4 ± 0.08
IL-17A	1.6 ± 0.08	1.8 ± 0.08	1.8 ± 0.1	4.1 ± 0.08	3.6 ± 0.09
Th2; % TCD4+/
IL-4	2.6 ± 0.1	1.8 ± 0.09	2.4 ± 0.1	1.6 ± 0.1	4.4 ± 0.1
IL-5	2.1 ± 0.1	1.4 ± 0.1	2.6 ± 0.1	1.9 ± 0.1	3.4 ± 0.1
IL-6	1.8 ± 0.1	1.7 ± 0.08	1.7 ± 0.1	1.5 ± 0.09	2.6 ± 0.07
IL-10	1.6 ± 0.08	1.5 ± 0.1	2.2 ± 0.1	1.2 ± 0.1	2.9 ± 1.6
TGF-β	1.5 ± 0.06	1.3 ± 0.8	2.3 ± 0.07	1.5 ± 0.08	5.1 ± 0.1

Data are presented as means ± standard deviations of percentage of TCD4+ cells producing cytokines. One-way ANOVA for comparison of differences between BL group at 8 weeks versus all the groups at 16 weeks. value was significant at <0.05.