The Novelty of Icosapent Ethyl in the Management of Hypertriglyceridemia and Alleviating Cardiovascular Risk

Figure 1

Triglyceride synthesis pathway and mechanism of action of omega-3 FA (fatty acid): In step (1), monoacylglycerol and FA-CoA combine to form diacylglycerol. This step is mediated by the MGAT enzyme. In step (2), diacylglycerol combine with another FA-CoA to form triacylglycerol, final step in triglyceride synthesis pathway. This last step is mediated by DGAT enzyme. This enzyme is inhibited by omega-3 FA, including IPE. Abbreviations: FA-CoA: fatty acyl CoA; MGAT: monoacylglycerol acyltransferase; DGAT: diacylglycerol acyltransferase enzyme; IPE: icosapent ethyl.