Journal of Nucleic Acids / 2011 / Article / Fig 8

Review Article

Use of Specific Chemical Reagents for Detection of Modified Nucleotides in RNA

Figure 8

Cleavage of the dihydrouridine ring (a) upon reduction by sodium borohydride (NaBH4) and (b) at mild alkaline conditions. In both cases, cleavage of the dihydrouridine ring is followed by cleavage of the RNA chain.

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