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Journal of Nucleic Acids
Volume 2019, Article ID 3947123, 9 pages
https://doi.org/10.1155/2019/3947123
Review Article

Netrin Family: Role for Protein Isoforms in Cancer

1Amsterdam UMC, University of Amsterdam, Department of Vascular Medicine, Location Meibergdreef, Amsterdam, Netherlands
2Leiden University Medical Center, Department of Internal Medicine, Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden, Netherlands

Correspondence should be addressed to Janine Maria van Gils; ln.cmul@slignav.mj

Received 7 December 2018; Accepted 6 February 2019; Published 24 February 2019

Guest Editor: Vladimir Majerciak

Copyright © 2019 Caroline Suzanne Bruikman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Netrins form a family of secreted and membrane-associated proteins. Netrins are involved in processes for axonal guidance, morphogenesis, and angiogenesis by regulating cell migration and survival. These processes are of special interest in tumor biology. From the netrin genes various isoforms are translated and regulated by alternative splicing. We review here the diversity of isoforms of the netrin family members and their known and potential roles in cancer.