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Journal of Nanomaterials
Volume 2008, Article ID 312792, 7 pages
http://dx.doi.org/10.1155/2008/312792
Research Article

Mesoporous Silica Coated : Particles for Drug Release

1State Key Laboratory of Application of Rare Earth Resources, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
2Graduate School of the Chinese Academy of Sciences, Beijing 100049, China

Received 5 March 2007; Revised 10 July 2007; Accepted 6 August 2007

Academic Editor: Donglu Shi

Copyright © 2008 Deyan Kong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

: nanoparticles were successfully prepared by a polyol process using diethylene glycol (DEG) as solvent. After being coated with dense silica, these : nanoparticles can be coated with mesoporous silica using nonionic triblock copolymer (P 123) as structure-directing agent. The composite can load ibuprofen and release the drug in the PBS. The composite was characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), nitrogen absorption/desorption isotherms, fluorescence spectra, and UV/Vis absorption spectra, respectively. The composite particles have considerable large pore volume and large surface area. In addition, the composite still emits strong green fluorescence and can be used as fluorescent probes in drug delivery system.