The Amphiphilic Self-Assembling Peptide EAK16-I as a Potential Hydrophobic Drug Carrier

Table 1

Transfer rates of molecular pyrene from EAK16-I coated pyrene microcrystals into a solution of EPC vesicles.

Molecular ratios of EAK16-I-to-pyrene^(a)	[𝑃𝑌𝑉]^(𝑏)(𝜇𝑚𝑜𝑙⋅𝐿^−1)	Rate constants of transfer (k) (h^−1)
0.061	13.3	7.92±0.01
0.229	15.6	2.30±0.01
0.061	63.7	6.52±0.06
0.229	61.4	1.85±0.01
0.229	62.6^(d)	1.63±0.01
0.061	104.2^(c)	fast: 7.10±0.09(78.11%); slow: 0.60±0.02(21.89%)

^(a) molecular ratios of EAK16-I-to-pyrene for E05P10 (0.061) and E05P02 (0.229) solution.
^(b) pyrene concentrations in the solutions of EPC vesicles at the end points of each transfer experiment.
^(c) two exponentials were needed to fit the release profile according to [𝑃𝑌](𝑡)=[𝑃𝑌]_(𝑡=∞)×[1−𝑝_{𝑓𝑎𝑠𝑡}×exp(−𝑘_{𝑓𝑎𝑠𝑡}𝑡)−𝑝_{𝑠𝑙𝑜𝑤}×exp(−𝑘_{𝑠𝑙𝑜𝑤}𝑡)] where 𝑝_{𝑓𝑎𝑠𝑡} and 𝑝_{𝑠𝑙𝑜𝑤} represent the proportion of fast release and slow release in overall release, respectively, and 𝑝_{𝑓𝑎𝑠𝑡}+𝑝_{𝑠𝑙𝑜𝑤}=100%.
^(d) from settled E05P02 solution.