Production of L-Leucine Nanoparticles under Various Conditions Using an Aerosol Flow Reactor Method

Table 1

Characteristics of L-leucine nanoparticles produced using different precursor solution concentrations and at different temperatures in the reactor heated zone.

𝐶le [g/l]	𝐶reactor [g/m^3]	𝑇reactor=110^∘C					𝑇reactor=150^∘C				𝑇reactor=200^∘C
		𝑆^′max	𝑑g [nm]	𝑑m [nm]	GSD	N [1/cm^3]	𝑆^′max	𝑑g [nm]	GSD	N [1/cm^3]	𝑆^′max	𝑑g [nm]	GSD	N [1/cm^3]
1.1	0.012	38	99	418	2.0	5.8×10^5	0.48	31	1.8	2.7×10^5	0.0058	28	1.7	1.9×10^5
2.2	0.029	93	123	520	2.0	8.1×10^5	1.16	61	1.5	5.1×10^5	0.014	35	1.5	3.5×10^5
4.3	0.065	208	135	571	2.0	7.8×10^5	2.61	105	1.4	3.6×10^5	0.032	63	1.8	6.5×10^5
8.6	0.143	455	142	600	2.0	6.9×10^5	5.79	180	1.5	3.1×10^5	0.070	109	1.9	6.7×10^5
17.2	0.318	1020	150	782	2.1	8.2×10^5	12.8	209	1.7	3.4×10^5	0.16	162	1.9	1.7×10^6

𝐶_le is leucine concentration in the precursor solution, 𝐶_reactor is the actual leucine concentration in the reactor, 𝑇_reactor is the temperature in the heated zone, 𝑆^′_max is a descriptive saturation ratio (not a real condition) that would be obtained, if all L-leucine was in the vapour phase under these conditions, 𝑑_g is the geometric mean diameter, 𝑑_m is the mass median diameter calculated from 𝑑_g using a Hatch-Choate conversion equation for log-normal size distributions given in literature [17], GSD is the geometric standard deviation, and N is the particle number concentration.