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Journal of Nanomaterials
Volume 2010, Article ID 409320, 8 pages
http://dx.doi.org/10.1155/2010/409320
Research Article

Boron Drug Delivery via Encapsulated Magnetic Nanocomposites: A New Approach for BNCT in Cancer Treatment

1Institute of Chemical and Engineering Sciences, No. 1 Pesek Road, Jurong Island, Singapore 627833
2Department of Pharmacology, National University of Singapore, 18 Medical Drive, Kent Ridge, Singapore 117597
3Defence Medical & Environmental Research Institute, DSO National Laboratories, 27 Medical Drive, Singapore 117510
4Department of Chemistry, Southern Methodist University, Dallas, TX 75275-0314, USA
5Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, IL 60115-2862, USA

Received 16 December 2009; Accepted 12 March 2010

Academic Editor: Ali Eftekhari

Copyright © 2010 Yinghuai Zhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ortho-carborane cages have been successfully attached to modified magnetic nanoparticles via catalytic azide-alkyne cycloadditions between 1-R-2-butyl-Ortho- C 2 B 1 0 H 1 0 ( R = M e , 3 ; P h , 4 ) and propargyl group-enriched magnetic nanoparticles. A loading amount of 9.83 mmol boron atom/g starch-matrixed magnetic nanoparticles has been reached. The resulting nanocomposites have been found to be highly tumor-targeted vehicles under the influence of an external magnetic field (1.14T), yielding a high boron concentration of 51.4  šœ‡ g/g tumor and ratios of around 10 : 1 tumor to normal tissues.