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Journal of Nanomaterials
Volume 2010, Article ID 652048, 8 pages
Research Article

Silica-Coated Liposomes for Insulin Delivery

1Department of Chemical Engineering, Indian Institute of Technology Bombay, Mumbai 400076, India
2Piramal Life Sciences Limited, Research and Development Division, Mumbai 400063, India

Received 4 November 2009; Revised 14 March 2010; Accepted 22 March 2010

Academic Editor: Maryam Tabrizian

Copyright © 2010 Neelam Dwivedi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Liposomes coated with silica were explored as protein delivery vehicles for their enhanced stability and improved encapsulation efficiency. Insulin was encapsulated within the fluidic phosphatidylcholine lipid vesicles by thin film hydration at pH 2.5, and layer of silica was formed above lipid bilayer by acid catalysis. The presence of silica coating and encapsulated insulin was identified using confocal and electron microscopy. The native state of insulin present in the formulation was evident from Confocal Micro-Raman spectroscopy. Silica coat enhances the stability of insulin-loaded delivery vehicles. In vivo study shows that these silica coated formulations were biologically active in reducing glucose levels.