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Journal of Nanomaterials
Volume 2010, Article ID 898910, 5 pages
Research Article

Preparation and Characterization of Water-Soluble Chitosan Nanoparticles as Protein Delivery System

1College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China
2College of Public Health, Guangdong Pharmaceutical University, Guangzhou 510240, China

Received 6 July 2009; Revised 1 September 2009; Accepted 1 November 2009

Academic Editor: Gaurav Mago

Copyright © 2010 Hong-liang Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The objective of this study was to investigate the potential of water soluble chitosan as a carrier in the preparation of protein-loaded nanoparticles. Nanoparticles were prepared by ionotropic gelation of water-soluble chitosan (WSC) with sodium tripolyphosphate (TPP). Bovine serum albumin (BSA) was applied as a model drug. The size and morphology of the nanoparticles were investigated as a function of the preparation conditions. The particles were spherical in shape and had a smooth surface. The size range of the nanoparticles was between 100 and 400 nm. Result of the in vitro studies showed that the WSC nanoparticles enhance and prolong the intestinal absorption of BSA. These results also indicated that WSC nanoparticles were a potential protein delivery system.