Table of Contents Author Guidelines Submit a Manuscript
Journal of Nanomaterials
Volume 2011, Article ID 136052, 10 pages
http://dx.doi.org/10.1155/2011/136052
Research Article

An Evaluation on Transfection Efficiency of pHRE-Egr1-EGFP in Hepatocellular Carcinoma Cells Bel-7402 Mediated by PEI-MZF-NPs

1Medical School of Southeast University, Jiangsu Province, Nanjing 210009, China
2Taizhou People's Hospital, Yangzhou University, Jiangsu Province, Taizhou 225300, China

Received 12 June 2011; Accepted 20 June 2011

Academic Editor: Daxiang Cui

Copyright © 2011 Mei Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Hingorani, C. L. White, A. Merron et al., “Inhibition of repair of radiation-induced DNA damage enhances gene expression from replication-defective adenoviral vectors,” Cancer Research, vol. 68, no. 23, pp. 9771–9778, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. H. Tsurushima, X. Yuan, L. E. Dillehay, and K. W. Leong, “Radiation-inducible caspase-8 gene therapy for malignant brain tumors,” International Journal of Radiation Oncology Biology Physics, vol. 71, no. 2, pp. 517–525, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. X. J. Xu, L. H. Ding, L. X. Wang et al., “Construction of human Egr-1 promoter and its response to ionizing radiation in tumor cells,” Xi Bao yu Fen zi Mian yi Xue za Zhi, vol. 25, no. 11, pp. 973–975, 2009. View at Google Scholar · View at Scopus
  4. G. L. Semenza, “Targeting HIF-1 for cancer therapy,” Nature Reviews Cancer, vol. 3, no. 10, pp. 721–732, 2003. View at Google Scholar · View at Scopus
  5. G. Bartholomeusz, P. Cherukuri, J. Kingston et al., “In vivo therapeutic silencing of hypoxia-inducible factor 1 alpha (HIF-1α) using single-walled carbon nanotubes noncovalently coated with siRNA,” Nano Research, vol. 2, no. 4, pp. 279–291, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Rapisarda, M. Hollingshead, B. Uranchimeg et al., “Increased antitumor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition,” Molecular Cancer Therapeutics, vol. 8, no. 7, pp. 1867–1877, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. L. Marignol, R. Foley, T. D. Southgate, M. Coffey, D. Hollywood, and M. Lawler, “Hypoxia response element-driven cytosine deaminase/5-fluorocytosine gene therapy system: a highly effective approach to overcome the dynamics of tumour hypoxia and enhance the radiosensitivity of prostate cancer cells in vitro,” Journal of Gene Medicine, vol. 11, no. 2, pp. 169–179, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. T. Shibata, A. J. Giaccia, and J. M. Brown, “Development of a hypoxia-responsive vector for tumor-specific gene therapy,” Gene Therapy, vol. 7, no. 6, pp. 493–498, 2000. View at Google Scholar · View at Scopus
  9. B. Kealy, A. Liew, J. M. McMahon et al., “Comparison of viral and nonviral vectors for gene transfer to human endothelial progenitor cells,” Tissue Engineering—Part C, vol. 15, no. 2, pp. 223–231, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. H. Akita and H. Harashima, “Nonviral gene delivery,” Contributions to Nephrology, vol. 159, pp. 13–29, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Kaneda and Y. Tabata, “Non-viral vectors for cancer therapy,” Cancer Science, vol. 97, no. 5, pp. 348–354, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. E. Cohen-Sela, M. Chorny, D. Gutman et al., “Characterization of monocytes-targeted nanocarriers biodistribution in leukocytes in ex-vivo and in-vivo models,” Nano Biomedicine and Engineering, vol. 2, no. 2, pp. 91–99, 2010. View at Google Scholar
  13. B. Pan, D. Cui, Y. Sheng et al., “Dendrimer-modified magnetic nanoparticles enhance efficiency of gene delivery system,” Cancer Research, vol. 67, no. 17, pp. 8156–8163, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. C. Liu, “Research and development of nanopharmaceuticals in China,” Nano Biomedicine and Engineering, vol. 1, no. 1, pp. 1–12, 2009. View at Google Scholar
  15. E. Anton, K. Swetha, W. Thomas et al., “Dextran-based nanocarriers as efficient media delivery vehicles to cell production bioreactors,” Nano Biomedicine and Engineering, vol. 2, no. 2, pp. 126–132, 2010. View at Google Scholar
  16. D. Cui, Y. Han, Z. Li et al., “Fluorescent magnetic nanoprobes for in vivo targeted imaging and hyperthermia therapy of prostate cancer,” Nano Biomedicine and Engineering, vol. 1, no. 1, pp. 61–74, 2009. View at Google Scholar
  17. S. Chen, Y. Ji, Q. Lian et al., “Gold nanorods coated with multilayer polyelectrolyte as intracellular delivery vector of antisense oligonucleotides,” Nano Biomedicine and Engineering, vol. 2, no. 1, pp. 15–23, 2010. View at Google Scholar
  18. P. Huang, Z. Li, and J. Lin, “Photosensitizer-conjugated magnetic nanoparticles for in vivo simultaneous magnetofluorescent imaging and targeting therapy,” Biomaterials, vol. 32, pp. 3447–3458, 2011. View at Google Scholar
  19. G. Gao, P. Huang, Y. Zhang, K. Wang, W. Qin, and D. Cui, “Gram scale synthesis of superparamagnetic Fe3O4 nanoparticles and fluid via a facile solvothermal route,” vol. 13, no. 6, pp. 1782–1785, 2011. View at Publisher · View at Google Scholar
  20. J. Panyam and V. Labhasetwar, “Biodegradable nanoparticles for drug and gene delivery to cells and tissue,” Advanced Drug Delivery Reviews, vol. 55, no. 3, pp. 329–347, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. G. Bhakta, S. Mitra, A. Maitra et al., “DNA encapsulated magnesium and manganous phosphate nanoparticles: potential non-viral vectors for gene delivery,” Biomaterials, vol. 26, no. 14, pp. 2157–2163, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Liang, Y. Wang, J. Yu, C. Zhang, J. Xia, and D. Yin, “Surface modified superparamagnetic iron oxide nanoparticles: as a new carrier for bio-magnetically targeted therapy,” Journal of Materials Science, vol. 18, no. 12, pp. 2297–2302, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Mansouri, P. Lavigne, K. Corsi, M. Benderdour, E. Beaumont, and J. C. Fernandes, “Chitosan-DNA nanoparticles as non-viral vectors in gene therapy: strategies to improve transfection efficacy,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 57, no. 1, pp. 1–8, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. V. Vijayanathan, T. Thomas, and T. J. Thomas, “DNA nanoparticles and development of DNA delivery vehicles for gene therapy,” Biochemistry, vol. 41, no. 48, pp. 14085–14094, 2002. View at Publisher · View at Google Scholar · View at Scopus
  25. J. M. Wang, B. L. Xiao, J. W. Zheng, H. B. Chen, and S. Q. Zou, “Effect of targeted magnetic nanoparticles containing 5-FU on expression of bcl-2, bax and caspase 3 in nude mice with transplanted human liver cancer,” World Journal of Gastroenterology, vol. 13, no. 23, pp. 3171–3175, 2007. View at Google Scholar · View at Scopus
  26. X. Wang, B. Yu, Y. Wu, R. J. Lee, and L. J. Lee, “Efficient down-regulation of CDK4 by novel lipid nanoparticle-mediated siRNA delivery,” Anticancer Research, vol. 31, no. 5, pp. 1619–1626, 2011. View at Google Scholar
  27. Y. Liu, T. Wang, F. He et al., “An efficient calcium phosphate nanoparticle-based nonviral vector for gene delivery,” International Journal of Nanomedicine, vol. 6, pp. 721–727, 2011. View at Google Scholar
  28. M. B. Jesus, C. V. Ferreira, E. Paula et al., “Design of solid lipid nanoparticles for gene delivery into prostate cancer,” Journal of Controlled Release, vol. 148, no. 1, pp. e89–e90, 2010. View at Google Scholar
  29. D. Wang, Y. Lin, L. X. Gu et al., “Study on Properties of nano-sized antimony doped tin oxide suspension,” China Powder Science and Technology, vol. 1, pp. 10–13, 2004. View at Google Scholar
  30. F. Gao, B. F. Pan, W. M. Zheng, L. M. Ao, and H. C. Gu, “Study of streptavidin coated onto PAMAM dendrimer modified magnetite nanoparticles,” Journal of Magnetism and Magnetic Materials, vol. 293, no. 1, pp. 48–54, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. R. Goyal, R. Bansal, S. Tyagi, Y. Shukla, P. Kumar, and K. C. Gupta, “1,4-Butanediol diglycidyl ether (BDE)-crosslinked PEI-g-imidazole nanoparticles as nucleic acid-carriers in vitro and in vivo,” Molecular BioSystems, vol. 7, no. 6, pp. 2055–2065, 2011. View at Publisher · View at Google Scholar
  32. Q. S. Tang, D. S. Zhang, X. M. Cong, M. L. Wan, and L. Q. Jin, “Using thermal energy produced by irradiation of Mn-Zn ferrite magnetic nanoparticles (MZF-NPs) for heat-inducible gene expression,” Biomaterials, vol. 29, no. 17, pp. 2673–2679, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. A. Q. Zheng, X. R. Song, J. M. Yu et al., “Construction of a chimeric promoter HRE/CarG and its regulation of hypoxia and radition on liver cancer cell,” Chinese Journal of Cancer Biotherapy, vol. 12, no. 1, pp. 69–71, 2005. View at Google Scholar
  34. X. Cong, D. Zhang, Q. Tang, N. Gu, S. Zhao, and J. Zhang, “Biocompatibility of Mn0.5Zn0.5Fe2O4 nanoparticles used in tumor hyperthermia,” Journal of Southeast University (National Science Education), vol. 3, pp. 23–27, 2007. View at Google Scholar
  35. Q. S. Tang, D. S. Zhang, and N. Gu, “Synthesis and in vitro study of PEI-coated MneZn ferrite e a novel gene vector,” Journal of Functional Materials, vol. 38, Article ID 1268e72, 2007. View at Google Scholar
  36. O. Bayguinov, B. Hagen, and K. M. Sanders, “Substance P modulates localized calcium transients and membrane current responses in murine colonic myocytes,” British Journal of Pharmacology, vol. 138, no. 7, pp. 1233–1243, 2003. View at Publisher · View at Google Scholar · View at Scopus