Journal of Nanomaterials / 2011 / Article / Tab 1

Research Article

Optimization of the Preparation Process for an Oral Phytantriol-Based Amphotericin B Cubosomes

Table 1

Results of particle size measurement on three batches of blank cubosome dispersions prepared under different homogenization conditions.

Cubosome dispersionMean particle size (nm)PDI

Ultrasound only291.70 ± 37.400.250 ± 0.030
600 bar for 3 cycles290.00 ± 25.000.210 ± 0.024
600 bar for 6 cycles277.33 ± 4.160.191 ± 0.027
600 bar for 9 cycles275.33 ± 18.820.189 ± 0.009
1200 bar for 3 cycles259.66 ± 19.300.162 ± 0.010
1200 bar for 6 cycles259.67 ± 12.420.149 ± 0.027
1200 bar for 9 cycles241.00 ± 12.420.107 ± 0.027
1800 bar for 9 cycles248.67 ± 4.930.103 ± 0.016