5-Fluorouracil Encapsulated Chitosan Nanoparticles for pH-Stimulated Drug Delivery: Evaluation of Controlled Release Kinetics

Table 2

Average particle size of chitosan nanoparticles prepared at different chitosan/TPP ratios.¹

Chitosan : TPP ratio (v/v)	1.25 mg/mL chitosan : 1.25 mg/mL TPP	0.75 mg/mL chitosan : 0.5 mg/mL TPP
1 : 1	>1000*	>1000*
2 : 1	>1000*	148.8±1.1 (PDI: 0.066)
2.5 : 1	393.1±1.8 (PDI: 0.443)	152.6±3.3 (PDI: 0.232)
3 : 1	421.9±27.6 (PDI: 0.377)	162.3±7.8 (PDI: 0.367)
3.5 : 1	510.0±42.9 (PDI: 0.379)	178.1±2.9 (PDI: 0.295)

¹Tween 80 0.5% (v/v); measurements are performed three times.
*PDI > 1.00.