Effect of Surface-Modified Paclitaxel Nanowires on U937 Cells In Vitro: A Novel Drug Delivery Vehicle
Table 2
24, 48, and 72 hour incubation periods, respectively.
Time
Parameter
Untreated
FT
SM-PN
SM-PN
SM-PN
SM-PN
200 nm
80 nm
35 nm
18 nm
24 h
Total cells* (SD)
3.70 (0.126)
2.53 (0.12)
2.28 (0.16)
2.10 (0.14)
1.68 (0.15)
2.81 (0.13)
Nonviable cells* (SD)
0.18 (0.006)
1.12 (0.05)
1.02 (0.07)
0.81 (0.05)
0.71 (0.06)
1.22 (0.057)
% Nonviable (SD)
4.9 (0.17)
43.5 (2.07)
44.0 (3.1)
38.2 (2.6)
41.8 (3.6)
42.8 (2.12)
% Proliferation (SD)
106 (7.03)
40.7 (6.73)
26.8 (8.90)
16.7 (7.85)
−6.5 (8.17)
56 (7.53)
Total cells (SD)
7.98 (0.16)
2.02 (0.18)
2.03 (0.22)
1.78 (0.19)
1.48 (0.17)
1.91 (0.15)
48 h
Nonviable cells (SD)
0.40 (0.008)
1.69 (0.15)
1.82 (0.20)
1.50 (0.13)
1.47 (0.17)
1.49 (0.12)
% Nonviable (SD)
5.0 (0.10)
84.9 (7.93)
89.4 (9.7)
85.0 (9.8)
100 (12.8)
79.0 (6.6)
% Proliferation (SD)
344 (8.90)
12.0 (10.2)
13.0 (12.5)
−0.9 (10.8)
−17.6 (9.5)
6.0 (8.7)
Total cells (SD)
9.48 (0.18)
1.70 (0.24)
1.32 (0.19)
1.70 (0.23)
1.18 (0.15)
1.72 (0.18)
72 h
Nonviable cells (SD)
1.30 (0.025)
1.50 (0.21)
1.31 (0.19)
1.69 (0.23)
1.18 (0.15)
1.70 (0.18)
% Nonviable (SD)
13.7 (0.26)
89.7 (12.6)
100 (16.5)
100 (13.8)
100 (15.3)
99.9 (10.4)
% Proliferation (SD)
427 (10.2)
−5.5 (13.1)
−26.8 (10.7)
−5.65 (12.7)
−34.2 (8.2)
−4.6 (10.2)
SD: standard deviation.
*Total number of nonviable or viable cells . % nonviable cells = (number of nonviable cells)/Total number of cells 100. % Proliferation = (Total number of cells−initial number of cells)/initial number of cells 100.
