Journal of Nanomaterials / 2012 / Article / Tab 2

Research Article

Effect of Surface-Modified Paclitaxel Nanowires on U937 Cells In Vitro: A Novel Drug Delivery Vehicle

Table 2

24, 48, and 72 hour incubation periods, respectively.

TimeParameterUntreatedFTSM-PNSM-PNSM-PNSM-PN
200 nm80 nm35 nm18 nm

24 hTotal cells* (SD)3.70 (0.126)2.53 (0.12)2.28 (0.16)2.10 (0.14)1.68 (0.15)2.81 (0.13)
Nonviable cells* (SD)0.18 (0.006)1.12 (0.05)1.02 (0.07)0.81 (0.05)0.71 (0.06)1.22 (0.057)
% Nonviable (SD)4.9 (0.17)43.5 (2.07)44.0 (3.1)38.2 (2.6)41.8 (3.6)42.8 (2.12)
% Proliferation (SD)106 (7.03)40.7 (6.73)26.8 (8.90)16.7 (7.85)−6.5 (8.17)56 (7.53)

Total cells (SD)7.98 (0.16)2.02 (0.18)2.03 (0.22)1.78 (0.19)1.48 (0.17)1.91 (0.15)

48 hNonviable cells (SD)0.40 (0.008)1.69 (0.15)1.82 (0.20)1.50 (0.13)1.47 (0.17)1.49 (0.12)
% Nonviable (SD)5.0 (0.10)84.9 (7.93)89.4 (9.7)85.0 (9.8)100 (12.8)79.0 (6.6)
% Proliferation (SD)344 (8.90)12.0 (10.2)13.0 (12.5)−0.9 (10.8)−17.6 (9.5)6.0 (8.7)

Total cells (SD)9.48 (0.18)1.70 (0.24)1.32 (0.19)1.70 (0.23)1.18 (0.15)1.72 (0.18)

72 hNonviable cells (SD)1.30 (0.025)1.50 (0.21)1.31 (0.19)1.69 (0.23)1.18 (0.15) 1.70 (0.18)
% Nonviable (SD)13.7 (0.26)89.7 (12.6)100 (16.5)100 (13.8)100 (15.3)99.9 (10.4)
% Proliferation (SD)427 (10.2)−5.5 (13.1)−26.8 (10.7)−5.65 (12.7)−34.2 (8.2)−4.6 (10.2)

SD: standard deviation.
*Total number of nonviable or viable cells ( × 1 0 6 ) .
% nonviable cells = (number of nonviable cells)/Total number of cells × 100.
% Proliferation = (Total number of cells−initial number of cells)/initial number of cells × 100.

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.