Pulmonary Toxicity, Distribution, and Clearance of Intratracheally Instilled Silicon Nanowires in Rats

Figure 4

Indices of lung injury, lactate dehydrogenase (LDH) (a) and albumin (b), and inflammation, specific cytokines (c), were measured in the first fraction of BAL fluid at 1, 3, 7, 28, and 91 days after-intratracheal instillation with 10 (Si 10), 25 (Si 25), 50 (Si 50), 100 (Si 100), or 500 (Si 500) μg Si NW, or dispersion medium control (DM). *significantly greater than all groups within a time point; ^#significantly greater than DM, Si 10, Si 25, and Si 50; ^∧significantly greater than DM and Si 10; values are means ± standard error (𝑛=8 DM, 𝑛=4 Si NW; 𝑃<0.05).

(a)

(b)

(c)