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Journal of Nanomaterials
Volume 2012, Article ID 480626, 5 pages
Research Article

Magnetic Nanoparticle Hyperthermia Using Pluronic-Coated F e 3 O 4 Nanoparticles: An In Vitro Study

1Institute of Frontier Medical Sciences, Kyoto University, 53 Kawara-cho Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
2Department of Electrical and Computer Engineering, Yokohama National University, 79-5 Tokiwadai, Hodogaya-ku, Yokohama 240-8501, Japan

Received 13 January 2012; Accepted 16 March 2012

Academic Editor: Krasimir Vasilev

Copyright © 2012 Asahi Tomitaka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Magnetic nanoparticles are promising materials for hyperthermia treatment. The temperature rise under ac magnetic field, cytotoxicity, and in vitro hyperthermia effect of F e 3 O 4 nanoparticles coated with Pluronic f-127 were evaluated in this paper. The Pluronic-coated F e 3 O 4 nanoparticles exhibited no cytotoxic effect on HeLa cells. The optimal magnetic field of Pluronic-coated F e 3 O 4 nanoparticles was 16 kA/m (200 Oe) at the field strength of 210 kHz. Appropriate temperature rise significantly reduced the viability of HeLa cells and induced apoptosis.