Current versus time plot of buffer solution (lower trace) and buffer with λ-phage DNA molecules (upper trace) upon application of 0.4 V across the pore. Every dip in current profile represents a DNA molecule passing through the pore. The pulse widths are typically 2–10 ms in duration and are well resolved, as shown in the insets. The variations in peak height are attributed to the different conformation of each molecule, reprinted with permission from [60], Copyright 2003 American Chemical Society.
