Preparation of Folate-Conjugated Pluronic F127/Chitosan Core-Shell Nanoparticles Encapsulating Doxorubicin for Breast Cancer Treatment

Table 1

Particle sizes and zeta potentials of pluronic micelles, chitosan nanoparticles, and folate-conjugated chitosan nanoparticles in the absence and presence of DOX.

Condition	Particle diameter (nm)	% intensity	Zeta potential (mV)	pH
Nanoparticles
(i) Micelles	32.6±2.1	81.9	−4.8±1.3	7.12
(ii) Micelles with SDS	22.9±0.3	73.7	−11.4±0.6	7.06
(iii) Chitosan nanoparticles	34.1±7.1	94.4	6.2±3.6	4.70
(iv) Folate-conjugated chitosan nanoparticles	41.3±6.5	96.3	8.3±1.1	4.74
DOX-loaded Nanoparticles
(i) DOX-loaded micelles	33.7±1.0	53.1	−4.4±0.8	7.07
(ii) DOX-loaded micelles with SDS	20.3±1.0	55.6	−3.8±0.8	7.03
(iii) DOX-loaded chitosan nanoparticles	30.9±1.7	96.3	10.6±2.9	4.69
(iv) DOX-loaded folate-conjugated chitosan nanoparticles	37.4±2.0	94.9	12.9±2.3	4.71