Intra/Inter-Particle Energy Transfer of Luminescence Nanocrystals for Biomedical Applications
Multiple-step FRET-based QD biosensors. (a) The hybrid nanostructure of CdTe conjugated fluorescence polymers, which exploits the light harvesting and FRET donor properties of QD for detection of DNA hybridization. (b) The two-step QD-FRET system, where the first energy transfer occurs from QD to Dye 1 in polymeric matrix, followed by the second energy transfer from Dye 1 to DNA-labeling Dye 2. Thus both the polymer and DNA degradation in cells can be assessed by the combination of FRET-mediated emission. (c) The multiple dye-labeled DNA symmetrically arrays on the surface of QD. By excitation of the central QD donor, the energy transfer is relayed through the sequentially aligned dye-acceptors which emit from the visible to NIR portion of the spectrum.
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