Journal of Nanomaterials / 2012 / Article / Fig 2

Research Article

Self-Assembling Peptide Nanofiber Scaffold Enhanced with RhoA Inhibitor CT04 Improves Axonal Regrowth in the Transected Spinal Cord

Figure 2

Axonal regrowth in the SAPNS treatment groups. (A) Neurofilament (NF) immunohistochemistry staining shows numbers of NF-positive axons regenerated into the lesion sites with SAPNS+CT04 treatment (the NF immunoreactivities are in green). The blue area is the distribution of counterstained DAPI to show the gross structure of the injured spinal cord. (a) The high power magnification corresponding to the box area of (A) shows the NF positive axons in the center of the lesion area. (B) Quantification of the NF positive axons in the center of the lesion area showed the axonal regrowth was significantly improved by the SAPNS+CT04 implants compared to the SAPNS group ( 𝑃 < 0 . 0 5 ).

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