Control of In Vivo Transport and Toxicity of Nanoparticles by Tea Melanin
Figure 1
The effect of tea melanin on the accumulation of GNPs in the brain and hippocampus. Mice were divided into 6 groups: a control group receiving PBS; a melanin group receiving 0.3 or 0.5 mg/kg tea melanin; a 17 nm group receiving 10 mg/kg of 17 nm GNP; a 37 nm group receiving 10 mg/kg of 37 nm GNP; a 17 nm + M group receiving 10 mg/kg of 17 nm GNP and pretreated with 0.3 or 0.5 mg/kg melanin; a 37 nm + M group receiving 10 mg/kg of 37 nm GNP and pretreated with 0.3 or 0.5 mg/kg melanin. Each group included 30 mice. Six mice from each group were sacrificed on day 1, 7, 14, 21, and 28. The brain was carefully dissected and the hippocampus was separated. ICP-MS was performed to obtain the content of Au. (a) Deposition of Au in the hippocampus for mice receiving 0.3 mg/kg melanin. (b) Deposition of Au in the brain for mice receiving 0.3 mg/kg melanin. (c) Deposition of Au in the hippocampus for mice receiving 0.5 mg/kg melanin. (d) Deposition of Au in the brain for mice receiving 0.5 mg/kg melanin.
