Control of In Vivo Transport and Toxicity of Nanoparticles by Tea Melanin
Figure 2
Dose-dependence for melanin-suppression of Au deposition in the brain and the hippocampus. Mice were pretreated with melanin at 0.1, 0.3, or 0.5 mg/kg and received 10 mg/kg 17 nm or 37 nm GNPs. The accumulation of Au on day 21 was obtained. (a) Accumulation of 17 nm GNP (left) and 37 nm GNP (right) in the brain. (b) Accumulation of 17 nm GNP (left) and 37 nm GNP (right) in the hippocampus.
