Control of In Vivo Transport and Toxicity of Nanoparticles by Tea Melanin

Figure 3

The effect of melanin pretreatment on GNP-induced cognition impairment. A passive avoidance test using light/dark rooms was performed. The latency time profiles on day 21 are shown for mice pretreated with 0.3 mg melanin/kg (a) and 0.5 mg melanin/kg (b). Each group of columns contains, in sequence, the averaged values from the control group (control), the melanin-treated only group (M), the scopolamine-treated group (scopolamine), the 17 nm GNP-treated group (17 nm), the 37 nm GNP-treated group (37 nm), the melanin pretreatment-plus 17 nm GNP-treated group (M + 17 nm), and the melanin pretreatment-plus 37 nm GNP-treated group (M + 37 nm). *represents 𝑃<0.05 and **represents 𝑃<0.001 from the student’s t-test.

(a)

(b)