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Journal of Nanomaterials
Volume 2012 (2012), Article ID 759830, 13 pages
Review Article

Nanobiosensors Based on Localized Surface Plasmon Resonance for Biomarker Detection

1Department of Biomedical Engineering, Yonsei University, Wonju, Gangwondo 220-710, Republic of Korea
2Department of Radiology, College of Medicine, Yonsei University, Seoul 120-749, Republic of Korea
3Severance Biomedical Science Institute (SBSI), Seoul 120-752, Republic of Korea
4YUMS-KRIBB Medical Convergence Center, College of Medicine, Yonsei University, Seoul 120-749, Republic of Korea
5Severance Integrative Research Institute for Cerebral & Cardiovascular Diseases, Yonsei University Health System, Seoul 120-752, Republic of Korea

Received 14 March 2012; Revised 5 August 2012; Accepted 5 August 2012

Academic Editor: Miguel A. Correa-Duarte

Copyright © 2012 Yoochan Hong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Localized surface plasmon resonance (LSPR) is induced by incident light when it interacts with noble metal nanoparticles that have smaller sizes than the wavelength of the incident light. Recently, LSPR-based nanobiosensors were developed as tools for highly sensitive, label-free, and flexible sensing techniques for the detection of biomolecular interactions. In this paper, we describe the basic principles of LSPR-based nanobiosensing techniques and LSPR sensor system for biomolecule sensing. We also discuss the challenges using LSPR nanobiosensors for detection of biomolecules as a biomarker.