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Journal of Nanomaterials
Volume 2012 (2012), Article ID 816496, 10 pages
Research Article

Mesoporous Silica SBA-16 Functionalized with Alkoxysilane Groups: Preparation, Characterization, and Release Profile Study

1Laboratório de Materiais Nanoestruturados para Bioaplicações, Centro de Desenvolvimento da Tecnologia Nuclear, Av. Antônio Carlos 6.627, Pampulha, 31270-901 Belo Horizonte, MG, Brazil
2Universidade Estadual de Campinas—Instituto de Química, Cidade Universitária Zeferino Vaz Distrito de Barão Geraldo, 13083-970 Campinas, SP, Brazil

Received 8 March 2012; Accepted 22 May 2012

Academic Editor: Anukorn Phuruangrat

Copyright © 2012 Gracielle Ferreira Andrade et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A mesoporous material sphere based on silica, SBA-16, was chemically modified with alkoxysilane using two different solvents: methanol and toluene. The influence of the chemical modification of the matrix on the release rate of a model drug was also studied. The structural characteristics of the materials were evaluated by small-angle X-ray diffraction, N2 adsorption, and transmission electron microscopy. The functionalization of the matrix was evaluated using thermal analysis, FTIR spectroscopy, 13C and 29Si solid-state nuclear magnetic resonance, and elemental analysis, CHN. The results show that alkoxysilane groups have been chemically bonded to silicon atoms on the surface of cubic Im3m mesoporous silica. The influence of the release rate of atenolol molecules from chemically modified mesoporous SBA-16 could be identified, since significant differences could be observed among the release patterns of the different materials.