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Journal of Nanomaterials
Volume 2012, Article ID 836394, 12 pages
Review Article

Preparation of Porous Biodegradable Polymer and Its Nanocomposites by Supercritical CO2 Foaming for Tissue Engineering

College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China

Received 8 December 2011; Revised 14 February 2012; Accepted 14 February 2012

Academic Editor: Suprakas Sinha Ray

Copyright © 2012 Xia Liao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Using supercritical carbon dioxide (scCO2) as an alternative to conventional methods in the preparation of porous biodegradable polymer and polymer/nanocomposites for tissue engineering has attracted increasing interest in recent years due to the absence of using organic solvents and the ability to incorporate thermosensitive biologicals without loss of bioactivity. Additionally, scCO2 can exert a high level of control over porosity and morphology of scaffolds by tuning the processing parameters. This paper describes the newly achievements on the preparation of porous polymer materials using scCO2 foaming technology with focus on the porous biodegradable materials and its nanocomposites relevant to tissue engineering.