In Vitro Characterization of Pluronic F127 and D-𝜶-Tocopheryl Polyethylene Glycol 1000 Succinate Mixed Micelles as Nanocarriers for Targeted Anticancer-Drug Delivery

Table 2

The mean % inhibition and average IC₅₀ (𝜇M) of doxorubicin-loaded mixed micelles in MCF-7 and THP-1 cells. % inhibitions for equal concentrations of doxorubicin-loaded micelles are shown for a selected concentration only, data represented as mean ± SEM (𝑛=3), ^b = **𝑃<0.01 compared to free doxorubicin.

Sample	Mean inhibition (%)		Average IC50 (𝜇M)
	MCF-7	THP-1	MCF-7	THP-1
10 : 0	81.88 ± 0.72^b	76.17 ± 2.78^b	9.64 ± 0.31^b	1.16 ± 0.03^b
7 : 3	82.93 ± 1.77^b	80.59 ± 8.17^b	6.27 ± 0.08^b	0.25 ± 0.01^b
5 : 5	86.77 ± 2.90^b	83.07 ± 1.09^b	3.32 ± 0.13^b	0.22 ± 0.02^b
3 : 7	91.43 ± 3.51^b	89.45 ± 3.55^b	2.83 ± 0.18^b	0.18 ± 0.15^b
Doxorubicin	73.10 ± 4.90	69.80 ± 4.35	11.07 ± 0.07	2.20 ± 0.10