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Journal of Nanomaterials
Volume 2012, Article ID 930931, 11 pages
Research Article

Assessment of Pulmonary Fibrogenic Potential of Multiwalled Carbon Nanotubes in Human Lung Cells

1Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
2Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA

Received 13 January 2012; Revised 25 March 2012; Accepted 25 March 2012

Academic Editor: Ivo Iavicoli

Copyright © 2012 Anurag Mishra et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Effect of Survanta®-dispersed MWCNT on human lung alveolar epithelial cell (A549 cell) was tested. A549 cells were exposed to 0.02–0.6 µg/cm2 of non-dispersed (ND-MWCNT) or Survanta®-dispersed MWCNT (SD-MWCNT) for 48 h. Cell viability and proliferation were determined by cell counting and secreted TGF-β1 levels in the treated cell supernatants were measured by ELISA. Similar but less sensitive results were observed (S-1 and S-2).

  1. Supplementary Material 1
  2. Supplementary Material 2