Table of Contents Author Guidelines Submit a Manuscript
Journal of Nanomaterials
Volume 2012, Article ID 986454, 10 pages
Research Article

Fabrication and Application of Iron(III)-Oxide Nanoparticle/Polydimethylsiloxane Composite Cone in Microfluidic Channels

1Department of Mechanical Engineering, National Taiwan University, Taipei 10617, Taiwan
2Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan
3Department of Civil and Environmental Engineering, National University of Kaohsiung, Kaohsiung 81148, Taiwan

Received 4 May 2012; Accepted 5 December 2012

Academic Editor: Gaurav Mago

Copyright © 2012 Cheng-Chun Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This paper presented the fabrication and applications of an iron(III)-oxide nanoparticle/polydimethylsiloxane (PDMS) cone as a component integrated in lab on a chip. The two main functions of this component were to capture magnetic microbeads in the microfluid and to mix two laminar fluids by generating disturbance. The iron(III)-oxide nanoparticle/PDMS cone was fabricated by automatic dispensing and magnetic shaping. Three consecutive cones of 300 μm in height were asymmetrically placed along a microchannel of 2 mm in width and 1.1 mm in height. Flow passing the cones was effectively redistributed for Renolds number lower than . Streptavidin-coated magnetic microbeads which were bound with biotin were successfully captured by the composite cones as inspected under fluorescence microscope. The process parameters for fabricating the composite cones were investigated. The fabricated cone in the microchannel could be applied in lab on a chip for bioassay in the future.