Review Article
Nanoscaffolds for Guided Cardiac Repair: The New Therapeutic Challenge of Regenerative Medicine
Table 3
Biomaterials for MI treatment reported in literature, in the last decade.
| Biomaterial | Delivery strategies | Reference |
| Naturally derived materials | | | Alginate | Injectable | [80] | 3D scaffold | [76–79] | Chitosan | Injectable | [77] | Patches | [78, 79] | Collagen | Injectable | [80] | 3D scaffold | [76] | Patches | [77, 78] | Extracellular matrix | Injectable | [76] | Patches | [79] | Fibrin and fibrin glue | Injectable | [76] | 3D scaffold | [77–79] | Gelatin | Injectable | [76, 77] | Silk fibroin | Patches | [77] | Synthetic materials | | | PEG | Injectable | [76] | Films | [78] | PLA | 3D scaffold | [76, 77, 80] | PGA | 3D scaffold | [76, 77, 80] | PLGA | 3D scaffold | [76, 77, 80] | PU | 3D sheet | [76, 77] | PEU | 3D scaffold | [77] | PEUU | 3D scaffold | [76] | Patches | [77] | TMC | Films | [76] | PTMC | Films | [77] | DLLA | Films | [76] | PNIPAAm | Cell sheet | [76] | Injectable | [78] | PGCL | Patches | [76] | PGS | 3D scaffold | [77] | PCL | Patches | [77] | Self-assembling peptides | Injectable | [78, 79] | Other synthetic hydrogels | Injectable | [79] | Composites materials | | | -Caprolactone-co-L-lactide reinforced with PCLA, gelatin or PGA | Patches | [80] | PEUU with type I collagen | 3D scaffold | [76] | Poly(caprolactone) with type I collagen | 3D scaffold | [76] | Decellularized materials | | | Urinary bladder matrix, SIS | Injectable | [78] | Porcine ventricular and pericardial tissue | Patches | [78] |
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MTE: myocardial tissue engineering; 3D: three dimensional; PEG: poly(ethylene glycol); PLA: poly(lactic acid); PGA: poly(glycolic acid); PLGA: poly(lactic-co-glycolic acid); PU: polyurethane; PEU: polyester urethane; PEUU: Poly(ester urethane) urea; TMC: 1,3-trimethylene carbonate; PTMC: poly(1,3-trimethylene carbonate); DLLA: D,L-lactide; PNIPAAm: poly(N-isopropylacrylamide); PGCL: poly-co-caprolactone; PGS: poly(glycerol sebacate); PCL: poly(ε-caprolactone); PCLA: poly(L-lactide); SIS: small intestine submucosa.
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