Development of Lecithin Nanoemulsion Based Organogels for Permeation Enhancement of Metoprolol through Rat Skin

Table 3

Flux, release rate (𝑑𝑄/𝑑𝑡), regression coefficient (𝑅²) of the curve plotted from changes of 𝑑𝑄 against 𝑑𝑡, permeation (𝑃), and diffusion coefficient (𝐷) of different formulations through cellulose acetate membrane and (†) rat skin.

Formulation	Flux (µg/cm^2/min) ± SD	𝑑𝑄/𝑑𝑡 (µg/min) ± SD	* 𝑅^2 ± SD	𝑃 (cm/min) ± SD	𝐷 (cm^2/min) ± SD
F1	0.29±0.01	1.53±0.08	0.971±0.002	(2.46±0.28)×10^−4	(6.60±0.88)×10^−9
F2	9.66±0.30	51.38±1.59	0.993±0.001	(1.63±0.04)×10^−4	(2.67±0.16)×10^−6
F3	21.21±0.21	112.83±1.12	0.995±0.005	92.24±0.02)×10^−4	(6.38±0.16)×10^−6
F6	1.58±0.01	6.16±0.09	0.938±0.001	(2.76±0.04)×10^−5	(2.01±0.06)×10^−7
F7	0.93±0.03	4.96±0.19	0.991±0.002	(1.89±0.05)×10^−5	(4.83±0.39)×10^−8
F8	0.70±0.03	3.73±0.18	0.964±0.006	(1.98±0.09)×10^−5	(4.31±0.50)×10^−8
F9	1.25±0.02	6.66±0.13	0.995±0.002	(2.92±0.061)×10^−5	(2.03±0.07)×10^−7
F10	7.38±0.26	39.26±1.39	0.998±0.001	(4.61±0.20)×10^−5	(6.21±0.52)×10^−7
F11	43.00±1.03	228.68±5.46	0.964±0.003	(1.59±0.03)×10^−3	(2.65±0.52)×10^−4
F12	4.50±0.16	24.02±0.81	0.957±0.007	(4.64±0.19)×10^−5	(5.32±0.40)×10^−7
F13	9.00±0.13	47.92±0.70	0.993±0.001	(1.59±0.01)×10^−4	(2.87±0.07)×10^−6
F14	5.32±0.16	28.30±0.91	0.993±0.007	(1.33±0.11)×10^−6	(3.43±0.55)×10^−6
F15	5.32±0.16	28.30±0.91	0.987±0.001	(2.96±0.25)×10^−5	(2.11±0.30)×10^−7
F16	0.65±0.02	3.46±0.12	0.986±0.001	(1.93±0.06)×10^−5	(4.37±0.36)×10^−8
F17	2.62±0.03	13.96±0.17	0.993±0.001	(5.19±0.08)×10^−5	(7.11±0.24)×10^−7
†F2	3.38±0.17	18.00±0.89	0.961±0.001	(3.68±0.21)×10^−5	(8.29±0.27)×10^−7
†F11	22.24±0.21	118.30±1.21	0.987±0.001	(4.53±0.06)×10^−4	(2.76±0.05)×10^−5
†F10	3.07±0.20	16.37±1.04	0.960±0.001	(2.47±0.15)×10^−5	(5.32±0.83)×10^−8