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Journal of Nanomaterials
Volume 2013, Article ID 170201, 10 pages
http://dx.doi.org/10.1155/2013/170201
Research Article

Polymeric Nanosuspensions for Enhanced Dissolution of Water Insoluble Drugs

1Mawson Institute, University of South Australia, Mawson Lakes, SA 5095, Australia
2School of Engineering, University of South Australia, Mawson Lakes, SA 5095, Australia
3Ian Wark Research Institute, University of South Australia, Mawson Lakes, Adelaide, SA 5095, Australia

Received 2 August 2013; Accepted 1 September 2013

Academic Editor: Haifeng Chen

Copyright © 2013 Roya Yadollahi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of the present research is to formulate and evaluate polymeric nanosuspensions containing three model water insoluble drugs, nifedipine (NIF), carbamazepine (CBZ), and ibuprofen (IBU) with various physicochemical properties. The nanosuspensions were prepared from hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP) by a cosolvent technique with polyethylene glycol (PEG-300) and water as the cosolvents. Physicochemical and morphological characteristics of the nanosuspensions (particle size, polydispersity index, and crystallinity) have been correlated with the drug release behaviour. The effects of polymer, drug ratio on the physical, morphological, and dissolution characteristics of the drugs are reported. Drug release is significantly enhanced from the nanosuspensions; for example, the maximum NIF, IBU, and CBZ concentrations after 8-hour dissolution are increased approximately 37, 2, and 1.2 times, respectively, in comparison with the pure powdered drugs. Based on this solubilization enhancement performance, the nanosuspensions have potential for increasing the orally dosed bioavailability of NIF, IBU, and CBZ.