Journal of Nanomaterials / 2013 / Article / Tab 1

Research Article

Polymeric Nanosuspensions for Enhanced Dissolution of Water Insoluble Drugs

Table 1

Characteristics of model water insoluble drugs (NIF, CBZ, and IBU) and excipients (HPMC, PVP, PEG-300, and mannitol) used in this study.

Name and characteristicsStructure

Nifedipine
Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Appearance: a yellow crystalline powder
Molecular weight: 346.3
Solubility: practically insoluble in water, sparingly in dehydrated alcohol, freely in acetone
Indication: calcium channel blocker [23]
Log P: 2.2 [24]
Solubility in PBS (pH 7): 0.0056 g/L [25]
170201.table.001a

Carbamazepine
5H-dibenzo[b,f]azepine-5-carboxamide
Appearance: a white crystalline powder
Molecular weight: 236.3
Solubility: practically insoluble in water, soluble in alcohol and acetone
Indication: anticonvulsant and mood-stabilizing [23]
Log P: 2.67 [26]
170201.table.001c

PVP
Molecular weight: 29000
Specifications: improving the wettability, dissolution rate, and crystal inhibitor [20, 21, 27]
170201.table.001e

Ibuprofen
(RS)-2-(4-(2-methylpropyl)phenyl)propanoic acid
Appearance: a white to off-white crystalline powder
Molecular weight: 206.3
Solubility: practically insoluble in water, very soluble in alcohol and acetone, Chloroform, methyl alcohol, slightly soluble in ethyl acetate.
Indication: anti-inflammatory [23]
Log P: 3.6 [28]
Solubility in PBS (pH 7.4): 25.16 mcg/mL [29]
170201.table.001b

PEG-300
Monomer: ethylene oxide
Molecular weight: 285–315
Application: cosolvent
170201.table.001d

Mannitol
(2R,3R,4R,5R)-hexan-1,2,3,4,5,6-hexol
Application: converting the drug nanosuspensions to a stable solid form and easy redispersibility
170201.table.001f

HPMC
Molecular weight: 86000
Specifications: improving the wettability, dissolution rate, and crystal inhibitor [18, 19, 27]
170201.table.001g

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