Research Article
Polymeric Nanosuspensions for Enhanced Dissolution of Water Insoluble Drugs
Table 3
Kinetic release rate constants and correlation coefficients of various kinetic models (first 2 hours).
| Drug | Sample label | Zero order | First order | Hixson-Crowell | | | | | | |
| NIF | | 0.0038 | 0.9500 | 0.0471 | 0.9453 | 0.0068 | 0.9469 | | 0.0235 | 0.9260 | 0.2001 | 0.9015 | 0.0325 | 0.9099 | | 0.0195 | 0.7963 | 0.0881 | 0.7847 | 0.0177 | 0.7885 | | 0.0392 | 0.9858 | 0.1754 | 0.9751 | 0.0353 | 0.9790 |
| CBZ | A1 | 0.0045 | 0.0262 | 0.0010 | 0.0263 | 0.0005 | 0.0262 | A2 | 0.0214 | 0.8082 | 0.0045 | 0.8076 | 0.0025 | 0.8078 | A3 | 0.0064 | 0.7631 | 0.0014 | 0.7630 | 0.0008 | 0.7630 | A4 | 0.0171 | 0.6843 | 0.0038 | 0.6836 | 0.0020 | 0.6838 |
| IBU | A1 | 0.5817 | 0.9195 | 0.0230 | 0.9167 | 0.0220 | 0.9176 | A2 | 3.7847 | 0.9115 | 0.0230 | 0.9167 | 0.1531 | 0.8975 | A3 | 5.9004 | 0.9240 | 0.1435 | 0.9065 | 0.1614 | 0.9125 | A4 | 2.0760 | 0.9978 | 0.0387 | 0.9982 | 0.0475 | 0.9984 |
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