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Journal of Nanomaterials
Volume 2013, Article ID 174398, 9 pages
Research Article

Antifungal Applications of Ag-Decorated Hydroxyapatite Nanoparticles

1LIEC, UNESP-Univ Estadual Paulista, P.O. Box 355, 14801-907 Araraquara, SP, Brazil
2Department of Dental Materials and Prosthodontics, Araraquara Dental School, UNESP-Univ Estadual Paulista, 14801-903 Araraquara, SP, Brazil
3LIEC, CMDMC, Department of Chemistry, Universidade Federal de São Carlos (UFSCar), 13565-905, São Carlos, SP, Brazil

Received 1 February 2013; Revised 23 May 2013; Accepted 26 May 2013

Academic Editor: Mohamed Bououdina

Copyright © 2013 C. A. Zamperini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Pure hydroxyapatite (HA) and hydroxyapatite decorated with silver (HA@Ag) nanoparticles were synthesized and characterized. The antifungal effect of HA@Ag nanoparticles in a distilled water solution was evaluated against Candida albicans. The origin of the antifungal activity of the HA@Ag is also discussed. The results obtained showed that the HA nanorod morphology remained the same with Ag ions decorations on the HA structure which were deposited in the form of nanospheres. Interaction where occurred between the structure and its defect density variation in the interfacial HA@Ag and intrafacial HA region with the fungal medium resulted in antifungal activity. The reaction mechanisms involved oxygen and water adsorption which formed an active complex cluster. The decomposition and desorption of the final products as well as the electron/hole recombination process have an important role in fungicidal effects.