Table 2: Grading system of the macroscopic signs in the in vivo tolerance study for the colloidal system tested [23].

GradeDiscomfortCorneaConjunctivaDischargeLids

0No reactionNo alterationsNo alterationsNo dischargeNo swelling
1BlinkingMild opacityMild hyperemia
Mild edema
Mild discharge without moistened hairMild swelling
2Enhanced blinking
Intense tearing
Vocalizations
Intense opacityIntense hyperemia
Intense edema
Hemorrhage
Intense discharge with moistened hairObvious swelling