Cationic Gelatin Nanoparticles for Drug Delivery to the Ocular Surface: In Vitro and In Vivo Evaluation

Table 2

Grading system of the macroscopic signs in the in vivo tolerance study for the colloidal system tested [23].

Grade	Discomfort	Cornea	Conjunctiva	Discharge	Lids
0	No reaction	No alterations	No alterations	No discharge	No swelling
1	Blinking	Mild opacity	Mild hyperemia; Mild edema	Mild discharge without moistened hair	Mild swelling
2	Enhanced blinking; Intense tearing; Vocalizations	Intense opacity	Intense hyperemia; Intense edema; Hemorrhage	Intense discharge with moistened hair	Obvious swelling