Cationic Gelatin Nanoparticles for Drug Delivery to the Ocular Surface: In Vitro and In Vivo Evaluation

Table 3

Grading system of macroscopic signs in the in vivo tolerance study of the gelatin nanoparticles.

	Control*		Free TAMRA				GP(+) TAMRA
Time	0.5 h	4.0 h	0.5 h	2.0 h	4.0 h	16.0 h	0.5 h	2.0 h	4.0 h	16.0 h
Grade
Discomfort	0	0	0	0	0	0	0	0	0	0
Cornea	0	0	0	0	0	0	0	0	0	0
Conjunctive	0	0	0	0	1	0	0	0	1	0
Discharge	0	0	0	0	1	0	1	0	0	0

^∗𝑛=3.
GP: gelatin nanoparticles; TAMRA: tetramethyl rhodamine.