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Journal of Nanomaterials
Volume 2013, Article ID 351810, 12 pages
Research Article

Synthesis and Characterization of Drug-Loaded Poly( -caprolactone)/Silica Hybrid Nanofibrous Scaffolds

1Department of Dental Laboratory Science and Engineering, Korea University, Seoul 136-703, Republic of Korea
2Department of Orthopaedics, Korea University Medical Center, Guro Hospital, Seoul 152-703, Republic of Korea
3Department of Materials Science and Engineering, Seoul National University, Seoul 151-742, Republic of Korea

Received 19 July 2013; Revised 27 September 2013; Accepted 27 September 2013

Academic Editor: Raghavendra Hegde

Copyright © 2013 Kwan-Ha Shin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We produced drug-loaded poly( -caprolactone) (PCL)/silica hybrid nanofibrous scaffolds with various silica sol contents (0 vol%, 10 vol%, 15 vol%, and 20 vol%) using electrospinning and examined their physicochemical properties, mechanical properties, drug release behavior, and in vitro biocompatibility to evaluate their potential application for guided bone regeneration (GBR). The loading efficiency of tetracycline hydrochloride (TCH) drug was remarkably enhanced by hybridizing the PCL solution with the silica sol. All produced hybrid scaffolds had a highly nanofibrous structure, in which the silica phase was homogeneously hybridized with the PCL polymer, while preserving their intrinsic characteristics. This led to considerable increases in hydrophilicity and mechanical properties (e.g., ultimate tensile strength and elastic modulus). In addition, the release rate and cumulative maximum amounts of the TCH from the hybrid scaffolds significantly increased with increasing the silica content, while all produced hybrid nanofibrous scaffolds showed good biocompatibility assessed by in vitro cell tests.