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Journal of Nanomaterials
Volume 2013, Article ID 391832, 6 pages
Research Article

Axial Vascularization of Nano-HA/Collagen/PLA Composites by Arteriovenous Bundle

1Department of Orthopaedic Surgery, Peking Union Medical College Hospital, No. 1 Shuaifuyuan Hutong, Beijing 100730, China
2Department of Materials Science & Engineering, Tsinghua University, Beijing 100084, China

Received 4 June 2013; Accepted 28 June 2013

Academic Editor: Xiaoming Li

Copyright © 2013 Hai Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In previous studies, nano-hydroxyapatite/collagen/poly(L-lactic acid) (nHAC/PLA) composites have been prepared and confirmed to repair small sized bone defects. However, they are restricted to repair a large defect without sufficient oxygen and nutrition for cell survival. The result of this study confirmed that nHAC/PLA composites could be axially vascularized by being implanted intramuscularly with arteriovenous (AV) bundle (Group A) in the groins of rabbits. The combination with autologous bone marrow (Group B) could not enhance it the vascularization in early phase (2 weeks, ), but it could enhance in middle and later phases (6 and 10 weeks, ). It meant that nHAC/PLA could be prefabricated as a vascularized bone substitute for grafting.