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Journal of Nanomaterials
Volume 2013, Article ID 469261, 9 pages
Review Article

Molecular Design and Applications of Self-Assembling Surfactant-Like Peptides

1Nanomedicine Laboratory, West China Hospital, Sichuan University, Chengdu 610041, China
2Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu 610041, China

Received 17 July 2013; Accepted 12 August 2013

Academic Editor: Yuan Zhang

Copyright © 2013 Chengkang Tang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Self-assembling surfactant-like peptides have been explored as emerging nanobiomaterials in recent years. These peptides are usually amphiphilic, typically possessing a hydrophobic moiety and a hydrophilic moiety. The structural characteristics can promote many peptide molecules to self-assemble into various nanostructures. Furthermore, properties of peptide molecules such as charge distribution and geometrical shape could also alter the formation of the self-assembling nanostructures. Based on their diverse self-assembling behaviours and nanostructures, self-assembling surfactant-like peptides exhibit great potentials in many fields, including membrane protein stabilization, drug delivery, and tissue engineering. This review mainly focuses on recent advances in studying self-assembling surfactant-like peptides, introducing their designs and the potential applications in nanobiotechnology.