Acute Oral Toxicity and Kinetic Behaviors of Inorganic Layered Nanoparticles

Table 1

Organosomatic indices of organs in different groups of mice at 14 days after oral administration.

Organ	Control	5 mg/kg	50 mg/kg	300 mg/kg	2000 mg/kg
Brain	0.88±0.15	0.91±0.11	0.79±0.15	0.88±0.09	0.86±0.07
Heart	0.44±0.12	0.34±0.06	0.35±0.02	0.24±0.10	0.29±0.04
Intestine	7.04±0.49	6.03±0.33	6.34±0.36	5.59±1.00	5.89±0.90
Kidney	0.93±0.11	0.88±0.01	0.81±0.02	0.78±0.03	0.82±0.03
Liver	3.81±0.37	3.66±0.28	3.33±0.19	3.51±0.13	3.35±0.09
Lung	0.37±0.02	0.41±0.05	0.41±0.05	0.41±0.10	0.37±0.02
Spleen	0.24±0.09	0.23±0.04	0.27±0.03	0.21±0.05	0.28±0.02
Stomach	0.51±0.17	0.23±0.07	0.65±0.24	0.58±0.14	0.42±0.26

All treated groups showed statistically no significant differences from the control group (𝑃>0.05).