Acute Oral Toxicity and Kinetic Behaviors of Inorganic Layered Nanoparticles

Table 3

Pharmacokinetic parameters of different doses of LDH nanoparticles in mice after oral administration.

Dose	𝐶max (mg/L)	𝑇max (h)	AUC (h × mg/L)	𝑇1/2 (h)	MRT (h)
5 mg/kg	4.15±1.41	0.08±0.00	0.79±0.29	0.22±0.20	0.35±0.29
50 mg/kg	4.44±0.32	0.14±0.10	4.00±2.36	0.73±0.49	1.27±0.82
300 mg/kg	7.24±0.70	0.17±0.10	8.74±4.05	1.38±0.67	2.15±1.27
2000 mg/kg	9.36±1.92	0.21±0.08	11.96±6.29	1.86±0.10	3.14±0.57

𝐶_max: maximum concentration; 𝑇_max: time to maximum concentration; AUC: area under the plasma concentration-time curve; 𝑇_1/2: half-life; MRT: mean residence time.