Table of Contents Author Guidelines Submit a Manuscript
Journal of Nanomaterials
Volume 2013 (2013), Article ID 641502, 6 pages
http://dx.doi.org/10.1155/2013/641502
Research Article

Effects of Chitosan Alkali Pretreatment on the Preparation of Electrospun PCL/Chitosan Blend Nanofibrous Scaffolds for Tissue Engineering Application

1Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia (UTM), 81310 Skudai, Johor Bahru, Johor, Malaysia
2Advanced Membrane Technology Center, Universiti Teknologi Malaysia (UTM), 81310 Johor Bahru, Johor, Malaysia
3Faculty of Chemical Engineering, Department of Polymer, Universiti Teknologi Malaysia (UTM), 81310 Johor Bahru, Johor, Malaysia

Received 19 March 2013; Revised 12 July 2013; Accepted 23 July 2013

Academic Editor: Jin Zhang

Copyright © 2013 Fatemeh Roozbahani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. F. Stamatialis, B. J. Papenburg, M. Gironés et al., “Medical applications of membranes: drug delivery, artificial organs and tissue engineering,” Journal of Membrane Science, vol. 308, no. 1-2, pp. 1–34, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. N. Sultana and M. Wang, “PHBV/PLLA-based composite scaffolds fabricated using an emulsion freezing/freeze-drying technique for bone tissue engineering: surface modification and in vitro biological evaluation,” Biofabrication, vol. 4, no. 1, Article ID 015003, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. N. Sultana and T. H. Khan, “In vitro degradation of PHBV scaffolds and nHA/PHBV composite scaffolds containing hydroxyapatite nanoparticles for bone tissue engineering,” Journal of Nanomaterials, vol. 2012, Article ID 190950, 12 pages, 2012. View at Publisher · View at Google Scholar
  4. I. Armentano, M. Dottori, E. Fortunati, S. Mattioli, and J. M. Kenny, “Biodegradable polymer matrix nanocomposites for tissue engineering: a review,” Polymer Degradation and Stability, vol. 95, no. 11, pp. 2126–2146, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. R. Ravichandran, S. Sundarrajan, J. R. Venugopal, S. Mukherjee, and S. Ramakrishna, “Advances in polymeric systems for tissue engineering and biomedical applications,” Macromolecular Bioscience, vol. 12, no. 3, pp. 286–311, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Dobkowski, R. Kołos, J. Kamiński, and H. M. Kowalczyńska, “Cell adhesion to polymeric surfaces: experimental study and simple theoretical approach,” Journal of Biomedical Materials Research, vol. 47, no. 2, pp. 234–242, 1999. View at Publisher · View at Google Scholar
  7. H. Yoshimoto, Y. M. Shin, H. Terai, and J. P. Vacanti, “A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering,” Biomaterials, vol. 24, no. 12, pp. 2077–2082, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. C. M. Vaz, S. van Tuijl, C. V. C. Bouten, and F. P. T. Baaijens, “Design of scaffolds for blood vessel tissue engineering using a multi-layering electrospinning technique,” Acta Biomaterialia, vol. 1, no. 5, pp. 575–582, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. F. Chen, C. N. Lee, and S. H. Teoh, “Nanofibrous modification on ultra-thin poly(e-caprolactone) membrane via electrospinning,” Materials Science and Engineering C, vol. 27, no. 2, pp. 325–332, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. S.-C. Wong, A. Baji, and S. Leng, “Effect of fiber diameter on tensile properties of electrospun poly(ε-caprolactone),” Polymer, vol. 49, no. 21, pp. 4713–4722, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. K. Ohkawa, H. Kim, K. Lee, and H. Yamamoto, “Electrospun non-woven fabrics of poly(ϵ-caprolactone) and their biodegradation by pure cultures of soil filamentous fungi,” Macromolecular Symposia, vol. 216, no. 1, pp. 301–306, 2004. View at Publisher · View at Google Scholar
  12. A. K. Moghe, R. Hufenus, S. M. Hudson, and B. S. Gupta, “Effect of the addition of a fugitive salt on electrospinnability of poly(ε-caprolactone),” Polymer, vol. 50, no. 14, pp. 3311–3318, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. L. van der Schueren, B. de Schoenmaker, Ö. I. Kalaoglu, and K. de Clerck, “An alternative solvent system for the steady state electrospinning of polycaprolactone,” European Polymer Journal, vol. 47, no. 6, pp. 1256–1263, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. C. Mahoney, M. B. McCullough, J. Sankar, and N. Bhattarai, “Nanofibrous structure of chitosan for biomedical applications,” Journal of Nanomedicine and Biotherapeutic Discovery, vol. 2, no. 1, 2012. View at Publisher · View at Google Scholar
  15. K. Ohkawa, D. Cha, H. Kim, A. Nishida, and H. Yamamoto, “Electrospinning of chitosan,” Macromolecular Rapid Communications, vol. 25, no. 18, pp. 1600–1605, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. K. Sun and Z. H. Li, “Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning,” Express Polymer Letters, vol. 5, no. 4, pp. 342–361, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. X. Geng, O.-H. Kwon, and J. Jang, “Electrospinning of chitosan dissolved in concentrated acetic acid solution,” Biomaterials, vol. 26, no. 27, pp. 5427–5432, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. S. de Vrieze, P. Westbroek, T. van Camp, and L. van Langenhove, “Electrospinning of chitosan nanofibrous structures: feasibility study,” Journal of Materials Science, vol. 42, no. 19, pp. 8029–8034, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. N. Bhattarai, Z. Li, J. Gunn et al., “Natural-synthetic polyblend nanofibers for biomedical applications,” Advanced Materials, vol. 21, no. 27, pp. 2792–2797, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. K. Ziani, C. Henrist, C. Jérôme, A. Aqil, J. I. Maté, and R. Cloots, “Effect of nonionic surfactant and acidity on chitosan nanofibers with different molecular weights,” Carbohydrate Polymers, vol. 83, no. 2, pp. 470–476, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. L. Li and Y.-L. Hsieh, “Chitosan bicomponent nanofibers and nanoporous fibers,” Carbohydrate Research, vol. 341, no. 3, pp. 374–381, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Ignatova, K. Starbova, N. Markova, N. Manolova, and I. Rashkov, “Electrospun nano-fibre mats with antibacterial properties from quaternised chitosan and poly(vinyl alcohol),” Carbohydrate Research, vol. 341, no. 12, pp. 2098–2107, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. H. Homayoni, S. A. H. Ravandi, and M. Valizadeh, “Influence of the molecular weight of chitosan on the spinnability of chitosan/poly(vinyl alcohol) blend nanofibers,” Journal of Applied Polymer Science, vol. 113, no. 4, pp. 2507–2513, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Cooper, N. Bhattarai, and M. Zhang, “Fabrication and cellular compatibility of aligned chitosan-PCL fibers for nerve tissue regeneration,” Carbohydrate Polymers, vol. 85, no. 1, pp. 149–156, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Hong and G. Kim, “Fabrication of electrospun polycaprolactone biocomposites reinforced with chitosan for the proliferation of mesenchymal stem cells,” Carbohydrate Polymers, vol. 83, no. 2, pp. 940–946, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. M. P. Prabhakaran, J. R. Venugopal, T. T. Chyan et al., “Electrospun biocomposite nanofibrous scaffolds for neural tissue engineering,” Tissue Engineering A, vol. 14, no. 11, pp. 1787–1797, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. K. T. Shalumon, K. H. Anulekha, C. M. Girish, R. Prasanth, S. V. Nair, and R. Jayakumar, “Single step electrospinning of chitosan/poly(caprolactone) nanofibers using formic acid/acetone solvent mixture,” Carbohydrate Polymers, vol. 80, no. 2, pp. 414–420, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. L. van der Schueren, I. Steyaert, B. de Schoenmaker, and K. de Clerck, “Polycaprolactone/chitosan blend nanofibres electrospun from an acetic acid/formic acid solvent system,” Carbohydrate Polymers, vol. 88, no. 4, pp. 1221–1226, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. X. Yang, X. Chen, and H. Wang, “Acceleration of osteogenic differentiation of preosteoblastic cells by chitosan containing nanofibrous scaffolds,” Biomacromolecules, vol. 10, no. 10, pp. 2772–2778, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. H. Homayoni, S. A. H. Ravandi, and M. Valizadeh, “Electrospinning of chitosan nanofibers: processing optimization,” Carbohydrate Polymers, vol. 77, no. 3, pp. 656–661, 2009. View at Publisher · View at Google Scholar · View at Scopus