Table of Contents Author Guidelines Submit a Manuscript
Journal of Nanomaterials
Volume 2013, Article ID 826471, 7 pages
http://dx.doi.org/10.1155/2013/826471
Research Article

Triple-Component Drug-Loaded Nanocomposites Prepared Using a Modified Coaxial Electrospinning

1School of Materials Science & Engineering, University of Shanghai for Science and Technology, 516 Jungong Road, Yangpu District, Shanghai 200093, China
2School of Chemistry, University of Bristol, Bristol BS8 1TS, UK

Received 17 June 2013; Accepted 27 November 2013

Academic Editor: Gaurav Mago

Copyright © 2013 Wei Qian et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Triple-component nanocomposites for improved sustained drug release profiles are successfully fabricated through a modified coaxial electrospinning process, in which only organic solvent N,N-dimethylacetamide was used as sheath fluid. Using polyacrylonitrile (PAN) as filament-forming matrix, ibuprofen (IBU) as functional ingredient, and polyvinylpyrrolidone (PVP) as the additional component, the IBU/PVP/PAN triple-component nanocomposites had uniform structure and an average diameter of  nm and  nm when the contents of PVP in the nanofibers were 10.5% and 22.7%, respectively. The optimal sheath-to-core flow rate ratio was 0.11 under a total sheath and core fluid flow rate of 1.0 mL/h. Compared with the IBU/PAN composite nanofibers, the triple-component composites could release 92.1% and 97.8% of the contained IBU, significantly larger than a value of 73.4% from the former. The inclusion of PVP in the IBU/PAN could effectively avoid the entrapment of IBU in the insoluble PAN molecules, facilitating the in vitro release of IBU. The modified coaxial process and the resulted multiple component nanocomposites would provide new way for developing novel drug sustained materials and transdermal drug delivery systems.