Table of Contents Author Guidelines Submit a Manuscript
Journal of Nanomaterials
Volume 2013 (2013), Article ID 865024, 8 pages
http://dx.doi.org/10.1155/2013/865024
Research Article

Cytotoxic Effect of Nanocrystalline MgFe2O4 Particles for Cancer Cure

1Materials Synthesis and Characterization Laboratory (MSCL), Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
2Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia

Received 30 August 2013; Accepted 16 October 2013

Academic Editor: William W. Yu

Copyright © 2013 S. Kanagesan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Nanocrystalline magnesium ferrites (MgFe2O4) were produced with an average grain size of about 20 nm. Their structural, morphological, and magnetic characterizations were studied. The cytotoxic effects of MgFe2O4 nanoparticles in various concentrations (25, 50, 100, 200, 400, and 800 μg/mL) against MCF-7 human breast cancer cells were analyzed. MTT assay findings suggest the increased accumulation of apoptotic bodies with the increasing concentration of MgFe2O4 nanoparticles in a dose-dependent manner. Flow cytometry analysis shows that MgFe2O4 nanoparticles in 800 μg/mL concentration are more cytotoxic compared to vehicle-treated MCF-7 cells and suggests their potential utility as a drug carrier in the treatment of cancer.