A Mucoadhesive Electrospun Nanofibrous Matrix for Rapid Oramucosal Drug Delivery

Table 3

Targeted responses for constrained optimization of the film formulation.

Response	Lower	Target	Upper
Disintegration time (seconds)	12	13	20
Work of Adhesion (mJ)	0.3	0.4	0.7
Maximum detachment force (N)	0.2	0.3	0.45
AUCD at 1 minute	0.3	0.35	0.45
AUCP at 3 minutes	1.6	1.9	2