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Journal of Nanomaterials
Volume 2014 (2014), Article ID 129035, 8 pages
http://dx.doi.org/10.1155/2014/129035
Research Article

Release of the Diclofenac Sodium by Nanofibers of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Obtained from Electrospinning and Solution Blow Spinning

Laboratório Nacional de Nanotecnologia Para o Agronegócio (LNNA), Embrapa Instrumentação (CNPDIA), Rua XV de Novembro, 1452 Centro, 13.560-970 São Carlos, SP, Brazil

Received 22 January 2014; Revised 28 March 2014; Accepted 11 April 2014; Published 5 May 2014

Academic Editor: Zhongkui Hong

Copyright © 2014 Michelle Andrade Souza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Electrospun fibers are explored as a new system for controlled drug delivery. Novel techniques capable of obtaining polymer nanofibers have been reported in the literature. They include solution blow spinning (SBS), which is a technique to produce polymer nanofibers in the same range as electrospinning, using pressurized gas instead of high voltage. The present study investigates release characteristics of diclofenac sodium encapsulated at three concentrations (5, 10, and 20% w/v) in poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofibers made by electrospinning and SBS and determines the drug’s effect on fiber morphology and structural properties. PHBV nanofibers were characterized using scanning electronic microscopy, differential scanning calorimetry, and X-ray diffraction, and the release profile was examined via UV-Vis spectrophotometry. Both electrospinning and SBS encapsulated diclofenac sodium in PHBV membranes efficiently and effectively. The profile of the in vitro release of diclofenac sodium was dependent on drug concentration and temperature. The drug reduced crystallinity and increased flexibility.