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Journal of Nanomaterials
Volume 2014, Article ID 209049, 7 pages
Research Article

Fabrication of Nanohydroxyapatite/Poly(caprolactone) Composite Microfibers Using Electrospinning Technique for Tissue Engineering Applications

1Faculty of Biosciences and Medical Engineering (FBME), Universiti Teknologi Malaysia (UTM), Johor Bahru, 81310 Skudai, Johor, Malaysia
2Miniaturized Medical Devices Program, Institute of Microelectronics, Agency for Science, Technology and Research (A*STAR), Singapore 117685

Received 19 March 2014; Revised 5 June 2014; Accepted 16 June 2014; Published 25 June 2014

Academic Editor: Zhongkui Hong

Copyright © 2014 Mohd Izzat Hassan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Tissue engineering fibrous scaffolds serve as three-dimensional (3D) environmental framework by mimicking the extracellular matrix (ECM) for cells to grow. Biodegradable polycaprolactone (PCL) microfibers were fabricated to mimic the ECM as a scaffold with 7.5% (w/v) and 12.5% (w/v) concentrations. Lower PCL concentration of 7.5% (w/v) resulted in microfibers with bead defects. The average diameter of fibers increased at higher voltage and the distance of tip to collector. Further investigation was performed by the incorporation of nanosized hydroxyapatite (nHA) into microfibers. The incorporation of 10% (w/w) nHA with 7.5% (w/v) PCL solution produced submicron sized beadless fibers. The microfibrous scaffolds were evaluated using various techniques. Biodegradable PCL and nHA/PCL could be promising for tissue engineering scaffold application.