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Journal of Nanomaterials
Volume 2014, Article ID 345845, 12 pages
http://dx.doi.org/10.1155/2014/345845
Research Article

Hyaluronate Targeted Solid Lipid Nanoparticles of Etoposide: Optimization and In Vitro Characterization

1Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Centre, Isfahan University of Medical Sciences, P.O. Box 81745-359, Isfahan, Iran
2Department of Medicinal Chemistry, School of Pharmacy and Novel Drug Delivery Systems Research Centre, Isfahan University of Medical Sciences, P.O. Box 81745-359, Isfahan, Iran

Received 13 October 2013; Revised 25 January 2014; Accepted 10 February 2014; Published 18 March 2014

Academic Editor: Renyun Zhang

Copyright © 2014 Jaleh Varshosaz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. E. Guppy, P. D. Nathan, and G. J. S. Rustin, “Epithelial ovarian cancer: A review of current management,” Clinical Oncology, vol. 17, no. 6, pp. 399–411, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. P. A. Radice, P. A. Bunn Jr., and D. C. Ihde, “Therapeutic trials with VP-16-213 and VM-26: active agents in small cell lung cancer, non-Hodgkin's lymphomas, and other malignancies,” Cancer Treatment Reports, vol. 63, no. 8, pp. 1231–1239, 1979. View at Google Scholar · View at Scopus
  3. F. Cabanillas, F. B. Hagemeister, G. P. Bodey, and E. J. Freireich, “IMVP-16: an effective regimen for patients with lymphoma who have relapsed after initial combination chemotherapy,” Blood, vol. 60, no. 3, pp. 693–697, 1982. View at Google Scholar · View at Scopus
  4. G. Mathe, L. Schwarzenberg, and P. Pouillart, “Two epipodophyllotoxin derivatives, VM 26 and VP 16213, in the treatment of leukemias, hematosarcomas, and lymphomas,” Cancer, vol. 34, no. 4, pp. 985–992, 1974. View at Google Scholar · View at Scopus
  5. A. D. Ho, T. Lipp, G. Ehninger et al., “Combination of mitoxantrone and etoposide in refractory acute myelogenous leukemia-an active and well-tolerated regimen,” Journal of Clinical Oncology, vol. 6, no. 2, pp. 213–217, 1988. View at Google Scholar · View at Scopus
  6. P. J. O'Dwyer, B. Leyland-Jones, and M. T. Alonso, “Etoposide (VP-16-213). Current status of an active anticancer drug,” The New England Journal of Medicine, vol. 312, no. 11, pp. 692–700, 1985. View at Google Scholar · View at Scopus
  7. R. E. Taylor, T. J. McElwain, A. Barrett, and M. J. Peckham, “Etoposide as a single agent in relapsed advanced lymphomas. A phase II study,” Cancer Chemotherapy and Pharmacology, vol. 7, no. 2-3, pp. 175–177, 1982. View at Google Scholar · View at Scopus
  8. H. Li, X. Zhao, Y. Ma, G. Zhai, L. Li, and H. Lou, “Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles,” Journal of Controlled Release, vol. 133, no. 3, pp. 238–244, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Uner and G. Yener, “Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives,” International Journal of Nanomedicine, vol. 2, no. 3, pp. 289–300, 2007. View at Google Scholar
  10. S. Mukherjee, S. Ray, and R. S. Thakur, “Solid lipid nanoparticles: a modern formulation approach in drug delivery system,” Indian Journal of Pharmaceutical Sciences, vol. 71, no. 4, pp. 349–358, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. W. Mehnert and K. Mader, “Solid lipid nanoparticles: production, characterization and applications,” Advanced Drug Delivery Reviews, vol. 47, no. 2-3, pp. 165–196, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. R. H. Müller, K. Mäder, and S. Gohla, “Solid lipid nanoparticles (SLN) for controlled drug delivery—a review of the state of the art,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 50, no. 1, pp. 161–177, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. K. S. Yadav, K. Chuttani, A. K. Mishra, and K. K. Sawant, “Long circulating nanoparticles of etoposide using PLGA-MPEG and PLGA-pluronic block copolymers: characterization, drug-release, blood-clearance, and biodistribution studies,” Drug Development Research, vol. 71, no. 4, pp. 228–239, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. L. H. Reddy, R. K. Sharma, K. Chuttani, A. K. Mishra, and R. R. Murthy, “Etoposide-incorporated tripalmitin nanoparticles with different surface charge: formulation, characterization, radiolabeling, and biodistribution studies,” The AAPS Journal, vol. 6, no. 3, article e23, 2004. View at Google Scholar · View at Scopus
  15. L. Harivardhan Reddy, R. K. Sharma, K. Chuttani, A. K. Mishra, and R. S. R. Murthy, “Influence of administration route on tumor uptake and biodistribution of etoposide loaded solid lipid nanoparticles in Dalton's lymphoma tumor bearing mice,” Journal of Controlled Release, vol. 105, no. 3, pp. 185–198, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. G. Yordanov, R. Skrobanska, and A. Evangelatov, “Colloidal formulations of etoposide based on poly(butyl cyanoacrylate) nanoparticles: preparation, physicochemical properties and cytotoxicity,” Colloids and Surfaces B: Biointerfaces, vol. 101, pp. 215–222, 2013. View at Google Scholar
  17. E. Kiliay, M. Demirbilek, M. Türk, E. Güven, B. Hazer, and E. B. Denkbas, “Preparation and characterization of poly(3-hydroxybutyrate-co-3- hydroxyhexanoate) (PHBHHX) based nanoparticles for targeted cancer therapy,” European Journal of Pharmaceutical Sciences, vol. 44, no. 3, pp. 310–320, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. R. C. Savani, G. Cao, P. M. Pooler, A. Zaman, Z. Zhou, and H. M. DeLisser, “Differential involvement of the hyaluronan (HA) receptors CD44 and receptor for HA-mediated motility in endothelial cell function and angiogenesis,” Journal of Biological Chemistry, vol. 276, no. 39, pp. 36770–36778, 2001. View at Publisher · View at Google Scholar · View at Scopus
  19. B. A. Nevius, Y. P. Chen, J. L. Ferry, and A. W. Decho, “Surface-functionalization effects on uptake of fluorescent polystyrene nanoparticles by model biofilms,” Ecotoxicology, vol. 21, no. 8, pp. 2205–2213, 2012. View at Google Scholar
  20. G. Kremser, T. Rath, B. Kunert et al., “Structural characterisation of alkyl amine-capped zinc sulphide nanoparticles,” Journal of Colloid and Interface Science, vol. 369, no. 1, pp. 154–159, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Sun, Synthesis of gold-amine nanoparticles of various sizes using two different methods [M.S. thesis], Department of Chemistry, Kansas State University, 2010.
  22. Y. Luo, N. J. Bernshaw, Z. R. Lu, J. Kopecek, and G. D. Prestwich, “Targeted delivery of doxorubicin by HPMA copolymer-hyaluronan bioconjugates,” Pharmaceutical Research, vol. 19, no. 4, pp. 396–402, 2002. View at Publisher · View at Google Scholar · View at Scopus
  23. K. Akima, H. Ito, Y. Iwata et al., “Evaluation of antitumor activities of hyaluronate binding antitumor drugs: synthesis, characterization and antitumor activity,” Journal of Drug Targeting, vol. 4, no. 1, pp. 1–8, 1996. View at Google Scholar · View at Scopus
  24. A. Rosato, A. Banzato, G. de Luca et al., “HYTAD1-p20: a new paclitaxel-hyaluronic acid hydrosoluble bioconjugate for treatment of superficial bladder cancer,” Urologic Oncology: Seminars and Original Investigations, vol. 24, no. 3, pp. 207–215, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. D. Peer and R. Margalit, “Loading mitomycin C inside long circulating hyaluronan targeted nano-liposomes increases its antitumor activity in three mice tumor models,” International Journal of Cancer, vol. 108, no. 5, pp. 780–789, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. H. Lee, H. Mok, S. Lee, Y. K. Oh, and T. G. Park, “Target-specific intracellular delivery of siRNA using degradable hyaluronic acid nanogels,” Journal of Controlled Release, vol. 119, no. 2, pp. 245–252, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. H. Yun, D. J. Goetz, P. Yellen, and W. Chen, “Hyaluronan microspheres for sustained gene delivery and site-specific targeting,” Biomaterials, vol. 25, no. 1, pp. 147–157, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. J. Varshosaz, S. Eskandari, and M. Tabakhian, “Production and optimization of valproic acid nanostructured lipid carriers by the Taguchi design,” Pharmaceutical Development and Technology, vol. 15, no. 1, pp. 89–96, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. Y. Ataman-Önal, S. Munier, A. Ganée et al., “Surfactant-free anionic PLA nanoparticles coated with HIV-1 p24 protein induced enhanced cellular and humoral immune responses in various animal models,” Journal of Controlled Release, vol. 112, no. 2, pp. 175–185, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. V. Teeranachaideekul, E. B. Souto, V. B. Junyaprasert, and R. H. Müller, “Cetyl palmitate-based NLC for topical delivery of Coenzyme Q10: development, physicochemical characterization and in vitro release studies,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 67, no. 1, pp. 141–148, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. R. M. Mainardes and R. C. Evangelista, “PLGA nanoparticles containing praziquantel: effect of formulation variables on size distribution,” International Journal of Pharmaceutics, vol. 290, no. 1-2, pp. 137–144, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Wani, E. Muthuswamy, G. H. L. Savithra, G. Mao, S. Brock, and D. Oupický, “Surface functionalization of mesoporous silica nanoparticles controls loading and release behavior of mitoxantrone,” Pharmaceutical Research, vol. 29, no. 9, pp. 2407–2418, 2012. View at Publisher · View at Google Scholar · View at Scopus
  33. G. A. Castro, A. L. Coelho, C. A. Oliveira, G. A. B. Mahecha, R. L. Oréfice, and L. A. M. Ferreira, “Formation of ion pairing as an alternative to improve encapsulation and stability and to reduce skin irritation of retinoic acid loaded in solid lipid nanoparticles,” International Journal of Pharmaceutics, vol. 381, no. 1, pp. 77–83, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. Y. Zhao, M. B. Brown, and S. A. Jones, “The effects of particle properties on nanoparticle drug retention and release in dynamic minoxidil foams,” International Journal of Pharmaceutics, vol. 383, no. 1-2, pp. 277–284, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Hossann, T. Wang, M. Wiggenhorn et al., “Size of thermosensitive liposomes influences content release,” Journal of Controlled Release, vol. 147, no. 3, pp. 436–443, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. M. M. A. Abdel-Mottaleb, D. Neumann, and A. Lamprecht, “In vitro drug release mechanism from lipid nanocapsules (LNC),” International Journal of Pharmaceutics, vol. 390, no. 2, pp. 208–213, 2010. View at Publisher · View at Google Scholar · View at Scopus