Scaffolding Biomaterials for Cartilage Regeneration

Table 2

Biochemical modification on scaffolds.

Modifier	Scaffolds	Effect	References
Surface peptide	PCL	Enhance the MSCs recruitment and provide a high specific affinity to MSCs	Shao et al., 2012 [24]
	Polyethylene oxide/chitin/chitosan	Enhance the adhesion and proliferation of bovine knee chondrocytes	Kuo and Wang, 2012 [25]
	PEO/chitosan scaffolds	Stimulate chondrogenesis with enhanced quantities of BKCs, glycosaminoglycans (GAGs), and collagen	Kuo and Wang, 2011 [26]
Bioglass	Agarose scaffolds	Improve the biochemical and mechanical properties of a tissue-engineered cartilage layer	Jayabalan et al., 2011 [27]
	PHBV	Improve the hydrophilicity of scaffolds and promote cell migration into the inner part of the constructs	Wu et al., 2013 [28]
Hyaluronic acid	Silk fibroin scaffolds	Protect the chondral phenotype and improve the structural and physical properties of scaffolds	Foss et al., 2013 [29]
	Gelatin-methacrylamide	Enhance the natural functions of scaffolds in cartilage mechanical and geometrical properties	Schuurman et al., 2013 [30]
	PLGA	Provide appropriate mechanical and structural properties of scaffolds for cells	Chang et al., 2013 [31]
	Collagen scaffolds	Improve cellular infiltration and promotes early-stage chondrogenesis	Matsiko et al., 2012 [32]
Chitosan	PLCL	Improve cells compatibility and form better quality cartilage tissue	Yang et al., 2012 [33]
	PLCL	Promote cell adhesion and proliferation and enhance excretion of aggrecan and type-II collagen	Li et al., 2012 [34]
	Silk fibroin scaffolds	Serve as excellent carrier for stem cells to repair cartilage defects	Deng et al., 2013 [35]
	Gelatin scaffolds	Enhance the cartilage regeneration in vitro and in vivo	Whu et al., 2013 [36]

PCL: polycaprolactone; MSCs: mesenchymal stem cells; PEO: polyethylene oxide; PHBV: polyhydroxybutyrate valerate; PLGA: poly(lactic-co-glycolic acid); PLCL: poly l-lactide-co-𝜀-caprolactone.